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Posted: April 27th, 2023
Write a 1-page narrative in APA format that addresses the following:
-Explain the circumstances under which children should be prescribed drugs for off-label use (this means the medication is used in a way that is not stated in the FDA labeling). . Be specific and provide examples. (Include drugs like the anticonvulsants Tegretol, Lamotrigine, topiramate divaloproex used for bipolar disorder in children. And other other drugs’ off label use for other mood/ psychiatric disorders for example depression and ADHD.
-Describe strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Include descriiptions and names of off-label drugs that require extra care and attention when used in pediatrics.
-Describe how children could respond differently to these drugs at different stages of life from infancy to adolescence. include 4 scholarly references at the end, APA, 2017-23
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Off-Label Use of Drugs in Children: Circumstances, Strategies, and Response
Off-label use of drugs in children is a controversial practice that involves using drugs in a way that is not FDA approved or indicated in the drug label. The off-label use of drugs in children is widespread and includes drugs like anticonvulsants Tegretol, Lamotrigine, topiramate, divalproex, and other drugs used for mood/psychiatric disorders like depression and ADHD. However, off-label use of drugs in children should only occur in certain circumstances where the potential benefits outweigh the risks.
One circumstance under which children may be prescribed drugs for off-label use is when there is no approved drug for the condition, and the off-label drug has been shown to be effective in clinical studies. For instance, the anticonvulsant Lamotrigine has been used off-label for the treatment of bipolar disorder in children, and there is evidence that it is effective in managing the condition. Another circumstance is when the drug has been approved for a different indication, and there is evidence that it may be effective for the current indication. For example, the use of the antipsychotic drug Risperdal has been approved for the treatment of schizophrenia in adults but has been used off-label to manage irritability in children with autism.
To make off-label use and dosage of drugs safer for children, healthcare providers need to take extra care and follow certain strategies. These strategies include informed consent, monitoring for adverse effects, and adjusting dosage according to age, weight, and medical history. Informed consent involves providing the child’s parents or guardians with complete information about the drug’s risks, benefits, and uncertainties. Healthcare providers should also monitor for adverse effects, especially in drugs like antipsychotics and antidepressants, which may have severe side effects. Finally, healthcare providers should adjust the dosage according to age, weight, and medical history to avoid underdosing or overdosing.
Off-label drugs that require extra care and attention when used in pediatrics include antipsychotics, antidepressants, and anticonvulsants. Antipsychotics such as Risperdal and Abilify can cause serious side effects like weight gain, diabetes, and movement disorders. Antidepressants like Prozac and Zoloft can cause suicidal thoughts and behavior, especially in adolescents. Anticonvulsants like Tegretol and topiramate can cause cognitive impairment and behavioral changes.
Children could respond differently to these drugs at different stages of life from infancy to adolescence. Infants may be more sensitive to the effects of certain drugs, and their immature metabolic system may require lower doses. Young children may experience different side effects than older children or adolescents, and they may require different dosage adjustments. Adolescents may have a higher risk of developing mood changes and suicidal behavior when using antidepressants and may require closer monitoring.
In conclusion, off-label use of drugs in children should only occur in certain circumstances where the potential benefits outweigh the risks. Healthcare providers need to follow certain strategies to make the off-label use and dosage of drugs safer for children, and they should adjust the dosage according to age, weight, and medical history. Finally, healthcare providers should be aware that children may respond differently to these drugs at different stages of life, and they should closely monitor for adverse effects.
References
American Academy of Child and Adolescent Psychiatry. (2018). Practice parameter for the use of atypical antipsychotic medications in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 57(10), 790-799.
Braun, C., & Berghella, V. (2017). Off-label use of drugs in pregnancy. American Journal of Obstetrics and Gynecology, 216(
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