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Posted: March 1st, 2023
Substance abuse Case Study
A 27-year-old patient with a history of substance abuse is found unresponsive by emergency medical services (EMS) after being called by the patient’s roommate. The roommate states that he does not know how long the patient had been lying there. The patient received naloxone in the field and has become responsive. He complains of burning pain over his left hip and forearm. Evaluation in the ED revealed a large amount of necrotic tissue over the greater trochanter as well as the forearm. EKG demonstrated prolonged PR interval and peaked T waves. Serum potassium level 6.9 mEq/L
Post an explanation of the disease highlighted in the scenario you were provided. Include the following in your explanation:
· The role genetics plays in the disease.
· Why the patient is presenting with the specific symptoms described.
· The physiologic response to the stimulus presented in the scenario and why you think this response occurred.
· The cells that are involved in this process.
· How another characteristic (e.g., gender, genetics) would change your response.
The disease highlighted in this scenario is likely acute drug toxicity, specifically from an overdose of opioids. The patient’s unresponsiveness and the administration of naloxone by EMS suggest opioid overdose, which is a common type of drug overdose. The patient’s complaints of burning pain over his left hip and forearm suggest possible tissue necrosis, which can occur as a complication of IV drug use.
Genetics can play a role in substance abuse and addiction, as there are genetic factors that contribute to an individual’s susceptibility to developing addictive behaviors. Studies have shown that genetic variations in the brain’s reward system, as well as in the metabolism of drugs, can increase the likelihood of addiction.
The patient is presenting with specific symptoms related to the effects of opioids on the body. Opioids act on the central nervous system to depress respiratory function, which can lead to respiratory arrest and unresponsiveness. The burning pain over the patient’s hip and forearm is likely related to tissue necrosis caused by injection drug use. The prolonged PR interval and peaked T waves seen on the EKG are consistent with hyperkalemia, which can occur as a complication of tissue breakdown and rhabdomyolysis, which can occur in cases of acute drug toxicity.
The physiologic response to opioid overdose is a depression of the central nervous system, resulting in respiratory depression, decreased level of consciousness, and potentially coma or death. Opioids also stimulate the release of histamine, which can cause vasodilation and hypotension. In addition, the breakdown of muscle tissue can result in hyperkalemia and cardiac arrhythmias.
The cells involved in the tissue necrosis seen in this patient are likely macrophages and neutrophils, which are part of the immune response to tissue damage. These cells release enzymes that break down damaged tissue and phagocytose cellular debris.
Another characteristic that could change the response to this scenario is the patient’s gender. Women are more likely to experience adverse effects from opioids, including respiratory depression, and are more likely to be prescribed opioids for pain. Additionally, genetic variations in drug metabolism may differ between men and women, which could affect the likelihood and severity of an overdose.
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